After more than four decades of involvement in nearly all aspects of direction, by identifying, qualifying, training, developing and consulting pioneers, to serving, like a pioneer, for several associations (large and small), I have frequently been asked, what I believe, to be, the most significant thing of principle, of contributing effectively. I have detected, and learned, while it is possible to teach somebody, and furnish them with the necessary and essential skills, to proceed, wisely, one has to start the procedure, having a particular type of mindset, and attitude. In case this must be summed – up, only, and essentially, it’d be, an individual must be directed by the core principle, todo, what’s perfect! Keeping that in mind, this article will try and briefly examine, consider, and talk, using the mnemonic approach, why understanding human nature. And/ or that which makes us, what we do, is crucial and important. Righteous; relevant; reactive; responsible; ramifications: It is crucial that you proceed, at a righteous manner, without being self – righteous! Just how could you understand what is relevant, until/ unless he pays keen attention, to the advantages and weaknesses, and the advantages, as well as drawbacks? Leading needs to concentrate on being attentive to needs, goals, priorities, and the mission of the group! A leader is responsible for effective leadership planning, and seeking strategic and action plans, together with sustainability, and achieving ramifications, as core components.