Following four decades of participation in the majority of elements of leadership, from identifying, qualifying, training, developing and consulting pioneers, to functioning, as a pioneer, for several organizations (small and large), I have frequently been asked, what I consider, to be, the most significant consideration of principle, of leading effectively. I’ve detected, and heard, whether it’s likely to train someone, and supply them with the needed and necessary abilities, to move, sensibly, an individual has to begin the procedure, using a specific sort of mindset, and attitude. In case that had to be summed – up, only, and essentially, it would be, one has to be guided by the core principle, to do, what’s appropriate! Bearing that in mind, this article will attempt to briefly examine, consider, and talk, with the mnemonic approach, why understanding human nature. And/ or that which causes us, what we do, is most crucial and important. Righteous; important; reactive; responsible; effects: It’s important to proceed, at a righteous manner, without having to be self – righteous! How might one know what is relevant, until/ unless he pays keen attention, to both the advantages and flaws, and also the advantages, as well as negatives? Leading needs to focus on being attentive to demands, aims, priorities, and the assignment of the group! A pioneer is accountable for effective leadership planning, and seeking strategic and action plans, with sustainability, and realizing consequences, as center components.