Following four years of participation in the majority of parts of direction, by identifying, qualifying, training, developing and consulting pioneers, to serving, as a leader, for all organizations (large and small), I have often been asked, what I consider, to be, the most important thing of rule, of contributing effectively. I have detected, and heard, whether it’s possible to train somebody, and furnish them with the necessary and essential abilities, to proceed, wisely, one has to start the procedure, with a certain sort of mindset, and attitude. In case that had to be summed – up, simply, and essentially, it’d be, one has to be guided by the core principle, to do, what’s appropriate! With that in mind, this guide will try and briefly examine, consider, and discuss, with the mnemonic approach, why understanding human nature. And/ or that which causes us do, what we do, is most important and relevant. Righteous; relevant; reactive; responsible; effects: It’s vital that you move, at a righteous manner, without being self – righteous! How might one understand what is relevant, until/ unless he pays keen attention, to the strengths and flaws, and the advantages, as well as negatives? Leading needs to concentrate on being responsive to demands, aims, priorities, and the assignment of the group! A pioneer is responsible for effective leadership preparation, and seeking strategic and action plans, together with sustainability, and realizing ramifications, as core components.