Following four decades of participation in nearly all aspects of direction,identifying, qualifying, training, developing and consulting leaders, to functioning, as a leader, for several associations (small and large), I’ve frequently been asked, what I think, to be, the most significant factor of principle, of leading efficiently. I’ve discovered, and learned, whether it is possible to teach some one, and supply them with the necessary and essential abilities, to proceed, wisely, an individual has to begin the method, having a particular kind of mindset, and attitude. In case that must be summed – up, simply, and essentially, it’d be, an individual must be directedthe heart principle, todo, what’s suitable! Bearing that in mind, this article will try and briefly examine, consider, and talk, with the mnemonic strategy, why understanding human nature. And/ or that which makes us do, what we do, is most important and relevant. It is critical to move in a righteous fashion, without having to be self – righteous! How might one know what’s relevant, until/ unless he pays keen attention, to both the strengths and flaws, and the advantages, in addition to drawbacks? Leading must focus on being responsive to needs, aims, priorities, and the assignment of this group! A leader is responsible for effective leadership preparation, and seeking tactical and action plans, together with sustainability, and understanding ramifications, as core components.