After more than four years of participation in nearly all parts of leadership,identifying, qualifying, training, consulting and developing leaders, to functioning, like a leader, for all organizations (large and small), I have frequently been asked, what I consider, to be, even the most important consideration of principle, of leading effectively. I’ve detected, and learned, while it is likely to coach some one, and furnish them, with the necessary and essential skills, to proceed, wisely, an individual has to start the procedure, using a specific kind of mindset, and attitude. In case that had to be summed – up, simply, and of course, it would be, an individual must be directedthe core principle, todo, what’s perfect! With that in mind, this article will attempt to briefly examine, consider, and discuss, together with the mnemonic approach, why understanding human nature. And/ or that which causes us do, that which we do, is crucial and important. Righteous; relevant; reactive; responsible; consequences: It’s important to proceed, at a righteous manner, without being self – righteous! How might one understand what’s relevant, until/ unless he pays keen attention, to the strengths and flaws, and the positives, in addition to drawbacks? Leading needs to focus on being responsive to needs, goals, priorities, and the mission of this bunch! A pioneer is responsible for effective leadership planning, and hunting tactical and action plans, with sustainability, and achieving ramifications, as center components.