After more than four decades of involvement in the majority of elements of direction, by identifying, qualifying, training, consulting and developing pioneers, to functioning, like a pioneer, for several organizations (small and large), I have often been asked, what I consider, to be, the most significant factor of rule, of leading efficiently. I’ve discovered, and heard, while it is likely to coach some one, and supply them, with the necessary and essential skills, to move, wisely, one has to start the process, with a particular sort of mindset, and attitude. If that must be summed – up, simply, and essentially, it would be, one must be guided by the core principle, to do, what’s perfect! Keeping that in mind, this guide will attempt to briefly examine, consider, and discuss, using the mnemonic approach, why understanding human nature. And/ or that which causes us do, what we do, is most important and relevant. Righteous; relevant; responsive; responsible; consequences: It is vital that you move, in a righteous fashion, without being self – righteous! Just how would you know what is relevant, until/ unless he pays keen attention, to the advantages and flaws, and the positives, in addition to negatives? Leading needs to focus on being responsive to needs, goals, priorities, and the mission of this group! A pioneer is accountable for effective leadership preparation, and seeking strategic and action plans, with sustainability, and realizing consequences, as core components.