Following four years of participation in the majority of parts of leadership,identifying, qualifying, training, developing and consulting leaders, to serving, as a leader, for several organizations (large and small), I’ve often been asked, what I consider, to be, the most important factor of principle, of contributing effortlessly. I’ve detected, and heard, whether it’s possible to train some one, and furnish them with the needed and necessary skills, to move, wisely, an individual must start the process, having a certain kind of mindset, and also attitude. If that must be summed – up, simply, and essentially, it’d be, an individual must be guidedthe core principle, to do, what’s perfect! With that in mind, this article will attempt to briefly examine, consider, and talk, with the mnemonic approach, why understanding human nature. And/ or that which makes us, that which we do, is most important and relevant. Righteous; relevant; responsive; responsible; effects: It is important to move, at a righteous manner, without being self – righteous! Just how could you understand what is relevant, until/ unless he pays keen attention, to the advantages and weaknesses, and also the positives, in addition to drawbacks? Leading must focus on being responsive to needs, goals, priorities, and the mission of this bunch! A pioneer is responsible for effective leadership preparation, and hunting tactical and action plans, together with sustainability, and achieving ramifications, as center components.